This page summarizes the full range of both experimental and approved interventions. The active ingredients in a medicine (Active Pharmaceutical Ingredients; APIs) include conventional small molecule drugs, vaccines, biologics (based upon recombinant DNA technologies), biologicals (derived from natural products), gene and cell therapies. This information includes the backgrounds of the medicines, clinical trials investigating their safety and efficacy, their intended (& approved) uses, sponsoring organizations, targets and mechanistic basis. We also compare the first FDA approval for any given drug (known as a new molecular entity; NME), from additional (secondary) NDA approvals and approvals for a generic form (known as ANDAs). Please note that since ClinicalTrials.gov is a comparatively recent dataset, the first clinical trial might occur after the approval of established medicines.
Approved APIs
Top 5 (by most trials)
human fecal microbiota (403) allogeneic hematopoietic stem cells (390) ciltacabtagene autoleucel (57) axicabtagene ciloleucel (31) autologous culture chondrocytes (30)Unapproved APIs
Top 5 (by most trials)
red blood cells (84) platelets (54)Experimental APIs with Trials
Top 5 (by most trials)
autologous hematopoietic stem cells (608) allogeneic adipose derived mesenchymal stem cell (320) umbilical cord mesenchymal stem cells (311) cd19 car-t cells (279) autologous mesenchymal stem cells (254)Approved APIs with Trials
Top 5 (by most trials)
human fecal microbiota (403) allogeneic hematopoietic stem cells (390) ciltacabtagene autoleucel (57) axicabtagene ciloleucel (31) autologous culture chondrocytes (30)Unapproved APIs with Trials
Top 5 (by most trials)
red blood cells (84) platelets (54)api_id | earliest_year | trade_api_name | Active Pharmaceutical Ingredient | Clinical Trial Years | Total Trials | Max Phase | Lead Sponsors | Approval Status | API Type |
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APIs with Innovator Approval
Top 5 (by most innovator approvals)
allogeneic hematopoietic stem cells (8) autologous culture chondrocytes (2) Allogeneic Cultured Keratinocytes and Fibroblasts in Bovine Collagen (2) axicabtagene ciloleucel (1) azficel-T (1)APIs with Generics Approval
Top 5 (by most generics approvals)
NoneNote: these approvals are sourced from Drugs@FDA and Purple Book, and do not currently reflect older FDA approvals and/or other evidence of US marketing.
api_id | earliest_year | trade_api_name | sponsor_org_id | Active Pharmaceutical Ingredient | Earliest NDA Sponsor | Approval Years | Innovator Approvals | Generics Approvals | Approval Status | API Type |
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